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Nima Aliakbarinodehi on Muck Rack

Nima Aliakbarinodehi

As seen in: BioRxiv
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Articles

Effects of Serum Incubation on Lipid Nanoparticle PEG Shedding, mRNA Retention, and Membrane Interactions

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By Simon Niederkofler, Petteri Parkkila, Nima Aliakbarinodehi
Introduction Click to copy section linkSection link copied! Translating mRNA-based therapies into clinical practice, particularly in protein replacement applications, requires the development of vehicles that ensure efficient and safe transport of these highly charged, high-molecular-weight therapeutics into target cells.
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Time-Resolved Inspection of Ionizable Lipid-Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Early Endosomal Membrane Mimic

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By Nima Aliakbarinodehi, Simon Niederkofler, Gustav Emilsson, Petteri Parkkila
| dx.doi.org
Introduction Click to copy section linkSection link copied! In mRNA therapeutics, endogenous cellular machineries are utilized to produce therapeutic proteins, thereby providing a promising means to treat a multitude of diseases where conventional medication strategies fail. (1,2) To overcome the inherent instability of mRNA and its low capacity to be naturally taken up by cells, a large number of viral and synthetic therapeutic vectors have been developed.
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Time Resolved Inspection of Ionizable-Lipid Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Endosomal Membrane Mimic

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By Erik Olsen Verified, Nima Aliakbarinodehi, Simon Niederkofler, Yujia Jing
| BioRxiv
Abstract This study investigates pH-triggered fusion dynamics of lipid nanoparticles (LNPs) with an endosomal membrane mimic, addressing mechanistic aspects of a crucial yet elusive process for effective mRNA delivery. Utilizing time-resolved total internal reflection fluorescence (TIRF) imaging, we observed a delayed onset of LNP fusion upon pH drop, lasting seconds to minutes depending on pH and LNP size.
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