Nina Judith Hos on Muck Rack

Nina Judith Hos

As seen in: The Journal of Immunology
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Articles

TRIM21 Is Targeted for Chaperone-Mediated Autophagy during Salmonella Typhimurium Infection

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By Nina Judith Hos, Julia Fischer, Deniz Hos, Zahra Hejazi
| The Journal of Immunology Verified
Open Access Nina Judith Hos, Julia Fischer, Deniz Hos, Zahra Hejazi, Chiara Calabrese, Raja Ganesan, Ambika M. V. Murthy, Jan Rybniker, Sharad Kumar, Martin Krönke and Nirmal Robinson J Immunol November 1, 2020, 205 (9) 2456-2467; DOI: https://doi.org/10.4049/jimmunol.2000048 Key Points IFN-I–inducible TRIM21 is degraded via CMA. S. Typhimurium activates mTORC2/Akt to impair CMA resulting in TRIM21 accumulation. High levels of TRIM21 contribute to S. Typhimurium–induced macrophage death.
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TRIM21 Is Targeted for Chaperone-Mediated Autophagy during Salmonella Typhimurium Infection

|
By Julia Fischer, Deniz Hos, Nina Judith Hos, Zahra Hejazi
| The Journal of Immunology Verified
Open Access Nina Judith Hos, Julia Fischer, Deniz Hos, Zahra Hejazi, Chiara Calabrese, Raja Ganesan, Ambika M. V. Murthy, Jan Rybniker, Sharad Kumar, Martin Krönke and Nirmal Robinson J Immunol September 18, 2020, ji2000048; DOI: https://doi.org/10.4049/jimmunol.2000048 Key Points IFN-I–inducible TRIM21 is degraded via CMA. S. Typhimurium activates mTORC2/Akt to impair CMA resulting in TRIM21 accumulation. High levels of TRIM21 contribute to S. Typhimurium–induced macrophage death.
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