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The facultative intracellular pathogen Listeria monocytogenes causes listeriosis, a rare but life-threatening disease. Host cell entry begins with activation of the human receptor tyrosine kinase MET through the bacterial invasion protein InlB, which contains an internalin domain, a B-repeat, and three GW domains. The internalin domain is known to bind MET, but no interaction partner is known for the B-repeat.
Author contributions: WMB and HHN designed the study and wrote the paper. WMB performed most experiments except FACS experiments. NL performed the FACS experiments and cloned the required proteins. ME designed and cloned the initial double and triple mutant vectors, purified the proteins and performed some of the MDCK colony scattering assays. DM cloned the single point mutations in InlB392 and prepared the proteins. CG purified full length InlB variants and conducted the ERK and AKT Western blots.
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