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Nina Steele on Muck Rack

Nina Steele

As seen in: Nature, Cancer Discovery
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Articles

Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-kB-mediated production of CXCL1

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By Samantha Kemp, Eileen S. Carpenter, Nina Steele, Katelyn Donahue
| cancerres.aacrjournals.org
Research Article Samantha B Kemp, Eileen S. Carpenter, Nina G Steele, Katelyn L Donahue, Zeribe Chike Nwosu, Amanda Pacheco, Ashley Velez-Delgado, Rosa E. Menjivar, Fatima Lima, Stephanie The, Carlos E Espinoza, Kristee Brown, Daniel Long, Costas A Lyssiotis, Arvind Rao, Yaqing Zhang, Marina Pasca di Magliano and Howard C Crawford DOI: 10.1158/0008-5472.CAN-20-3929 Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with few effective therapeutic options.
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Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer

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By Nina Steele, Eileen S. Carpenter, Samantha Kemp, Veerin R. Sirihorachai
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor microenvironment that renders it largely refractory to immunotherapy. We implemented a multimodal analysis approach to elucidate the immune landscape in PDA. Using a combination of CyTOF, single-cell RNA sequencing and multiplex immunohistochemistry on patient tumors, matched blood and non-malignant samples, we uncovered a complex network of immune-suppressive cellular interactions.
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Targeting the Microenvironment to Overcome Gemcitabine Resistance in Pancreatic Cancer

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By Eileen S. Carpenter, Nina Steele
| cancerres.aacrjournals.org
Cancer Research Highlights Eileen S. Carpenter, Nina G. Steele and Marina Pasca di Magliano DOI: 10.1158/0008-5472.CAN-20-1692 Published August 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract Pancreatic cancer is characterized by an extensive and complex microenvironment, and is resistant to both chemotherapy and immune checkpoint blockade.
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