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Nina T Cassidy on Muck Rack

Nina T Cassidy

As seen in: Nature, BioRxiv
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Articles

siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs - Nature Biomedical Engineering

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By Juan Colazo, Megan Keech, Veeraj Shah, Nina T Cassidy, Alexander Sorets, Danielle L. Michell, Katherine N. Gibson-Corley, Leslie J. Crofford
| Nature Verified
Abstract Osteoarthritis and rheumatoid arthritis are debilitating joint diseases marked by pain, inflammation and cartilage destruction. Current osteoarthritis treatments only relieve symptoms, while rheumatoid arthritis therapies can cause immune suppression and provide variable efficacy. Here we developed an optimized small interfering RNA targeting matrix metalloproteinase 13 for preferential delivery to arthritic joints.
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VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction

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By Harris Blankenship, Kelsey Carter, Nina T Cassidy, Andrea N Markiewicz
| BioRxiv
Abstract Alzheimer's disease (AD) patients exhibit neuropsychiatric symptoms that extend beyond classical cognitive deficits, suggesting involvement of subcortical areas. Here, we investigated the role of midbrain dopamine (DA) neurons in AD using the amyloid + tau-driven 3xTg-AD mouse model. We found deficits in reward-based operant learning in AD mice, suggesting possible VTA DA neuron dysregulation.
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