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Ninfa Candela

As seen in: Nature, Healio, American Journal of Managed Care
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Articles by Ninfa Candela

An ulcerative colitis taxonomy defined by individual patient-reported response trajectories

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By Stefan Schreiber, Vijay Yajnik, Cenfu Wei, Maria D. Paraskevopoulou, Saman Farahmand, Jie Cheng, Katherine Simpson, Zitong Lin, Christian Agboton, Pratik Panchal, Banishree Saha, Ninfa Candela, Joshua Brown, Isabella Peshek, Frida Chavez, Libeth Rosas, Alan Robinson, Gursimran Kochhar, Aakash Desai, Franziska Kimmig, Philip Rosenstiel, Paresh Thakker, Parambir S Dulai
| Nature Verified
Abstract A barrier to precision medicine for ulcerative colitis (UC) is the inability to predict and mechanistically explain treatment responses. Using patient-reported outcomes (PROs) from a phase 3b comparative trial of 768 participants, we identified four distinct patient response-trajectory groups for vedolizumab (anti-integrin) and adalimumab (antitumor necrosis factor).
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Correction: Vitamin D status in pediatric irritable bowel syndrome

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By Benjamin Udoka Nwosu, Louise Maranda, Ninfa Candela
| PLOS
The Data Availability statement for this paper is incorrect. The correct statement is: Our study data files are publicly deposited in the University of Massachusetts Medical School’s institutional repository, eScholarship@UMMS. Please access the data at either of the following links: http://dx.doi.org/10.13028/M27P4Q http://escholarship.umassmed.edu/pediatrics_data/4/ Reference1. Nwosu BU, Maranda L, Candela N (2017) Vitamin D status in pediatric irritable bowel syndrome. PLoS ONE 12(2): e0172183.
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Vitamin D status in pediatric irritable bowel syndrome

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By Benjamin Udoka Nwosu, Louise Maranda, Ninfa Candela
| PLOS
Pediatric patients with IBS had significantly lower 25(OH)D concentration compared to controls despite having similar mean BMI values as controls. Only 7% of the children and adolescents with IBS were vitamin D sufficient, and >50% of the subjects with IBS had vitamin D deficiency. This is a much higher prevalence of vitamin D deficiency compared to IBD and other malabsorption syndromes. Monitoring for vitamin D deficiency should be part of the routine care for patients with IBS.
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