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Parambir S Dulai

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Articles

Persistence of mucosal CAR-T cells and inflammatory remodeling in enterocolitis associated with BCMA CAR-T cell therapy

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By Nikhit Kethidi, Saumya Pothukuchi, Adolfo López Alemán, Daniel Charytonowicz, Christina G. Kuhn, Thomas Wong, Jennifer D. Claytor, Pablo Canales-Herrerias, Samane Khoshbakht, Akanksha Acharya, Michael Tankelevich, Divya Jha, Matthias Ceulemans, Alexandra E. Livanos, Catherine Le Berre, Zachary M. Avigan, Luise Fischer, Jacqueline E. Birkness-Gartman, Joanna Melia, Yimei Jin, Isha Parikh, Meenakshi Mehrotra, Shriya Desai, Sidorela Reci, Kedwin Ventura, Rudra Prasad Dutta, Benjamin Gordon, Rachel Brody Verified, Charlotte Cunningham-Rundles, Zhihong Chen, Seunghee Kim-schulze, Parambir S Dulai, Shruti Naik, Jane Houldsworth, Maximilian Merz, Randy S. Longman, Ivan Zanoni, Jeremiah Faith, Jean-Frédéric Colombel, Britta Siegmund, Raja Atreya, Markus F. Neurath, Shambavi Richard, Sundar Jagannath, Jerome Martin, Eric Meffre, Mayte Suárez-Fariñas, David Muniz Pedrogo, Alexandros D. Polydorides, Samir Parekh, Saurabh Mehandru, Erika Patel
| Nature Verified
Abstract B cell-targeted therapies are expanding across oncologic and autoimmune indications, yet their consequences for mucosal immunity remain incompletely examined. Here we define the pathophysiology of ciltacabtagene autoleucel chimeric antigen receptor (CAR)-T cell-induced enterocolitis (EC) (CAR-TEC)—a severe complication of B cell maturation antigen-targeted CAR-T cell therapy in multiple myeloma.
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Butyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance

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By Tianming Yu, Wenjing Yang, Anthony J. Bilotta, Suxia Yao, Jeong-Heon Lee, Qihong Zhao, Jia Zhou, Tamas Ordog, Parambir S Dulai, Yingzi Cong
| Nature Verified
Abstract Intestinal epithelial cells (IEC) are the primary cell type in direct contact with stimuli from the luminal microbiota, playing a critical role in host-microbe interactions. However, how IECs communicate with underlying immune cells to maintain homeostasis remains poorly understood. In addition, the mechanisms by which IECs sense microbiota-derived stimuli to initiate this crosstalk are not yet fully understood.
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Sa1470 PHARMACOKINETICS AND TRANSCRIPTOMIC ANALYSIS REVEAL THE MOLECULAR SIGNATURE OF MUCOSAL HEALING IN PATIENTS WITH ACUTE SEVERE ULCERATIVE COLITIS TREATED WITH INFLIXIMAB (PROTOS)

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By Robert Battat, Luca Massimino, Lars Eckmann, Waseem Ahmed, Paris Charilaou, Brigid S. Boland, Siddharth Singh Verified, Parambir S Dulai, Marjolijn Duijvestein, Mark Silverberg, Randy S. Longman, Dana Lukin, Ellen J. Scherl, Pavine Lefevre, Matthew Rueffer
| Gastrointestinal Endoscopy Verified
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