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Ninghuan Li on Muck Rack

Ninghuan Li

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B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicities - Nature Communications

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By Jian Guan, Tiongsun Chia, Tianyu Zhu, Zhengguang Liao, Junjie Deng, Fenggen Fu, Weiwei Wu, Chengtao Liu, Ya Liu, Ninghuan Li, Lili Yue, Lei Cao, Jia Lu, Mengjia Zhu, Xiaomin Ling, Huilin Zheng, Shuming Lin, Shuaixiang Zhou, Kaijie He
| Nature Verified
Abstract Therapeutic targeting of epidermal growth factor receptor (EGFR) in solid tumors faces significant limitations due to on-target/off-tumor toxicities, underscoring the urgent need for tumor-selective anti-EGFR therapies. Comprehensive bioinformatics and histopathological analyses identify marked upregulation of B7-H3 across EGFR-positive malignancies, contrasting with its minimal expression in healthy tissues.
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