Nirupa Murugaesu on Muck Rack

Nirupa Murugaesu

As seen in: Nature, Inkl
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Articles

The genomic landscape of 2,023 colorectal cancers - Nature

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By Alex J. Cornish, Andreas Gruber, Ben Kinnersley, Anna Frangou, Giulio Caravagna, Boris Noyvert, Eszter Lakatos, Henry Wood, Steve Thorn, Richard Culliford, Claudia Arnedo-Pac, Jacob Househam, William Cross, Amit Sud, Philip J Law, Aliah Hawari, Connor Woolley, Kitty Sherwood, Nathalie Feeley, Ludmil B. Alexandrov, Nirupa Murugaesu, Nuria Lopez-Bigas, Philip Quirke, David Church Verified, Ian Tomlinson, Andrea Sottoriva, Trevor Graham, David C. Wedge, Alona Sosinsky
| Nature Verified
Abstract Colorectal carcinoma (CRC) is a common cause of mortality1, but a comprehensive description of its genomic landscape is lacking2,3,4,5,6,7,8,9. Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer.
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Whole-genome sequencing data ‘can transform cancer care with tailored therapy’

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By Nirupa Murugaesu
| Inkl
PA Archive A comprehensive test that analyses a patient’s complete set of genetic material “can transform cancer care” in the NHS by helping doctors provide them with more personalised treatments, scientists have said. In the largest study of its kind, researchers have found that combining clinical health data with information gathered from whole-genome sequencing tests – which determines a person’s genetic make-up – can provide cancer patients with tailored care.
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