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Nirvanjyoti Sharma Shimul on Muck Rack

Nirvanjyoti Sharma Shimul

As seen in: Nature
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Articles

The kinase SPE-55 promotes localized assembly of the major sperm protein in Caenorhabditis elegans spermatocytes

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By T. Andrew, Guinevere E. Ashley, Jake Diaz, Jordan Ward, Diane C. Shakes, Nirvanjyoti Sharma Shimul, James Matthew Ragle, Sofia De La Vega Mireles, Matthew J. Wawersik
| Nature Verified
Abstract The crawling motility of nematode sperm is driven by the unconventional cytoskeletal protein, Major Sperm Protein (MSP). In developing spermatocytes, MSP assembles on the cytosolic side of Golgi-derived membranous organelles (MOs) in structures called Fibrous Bodies (FBs). These MSP-laden FB-MO complexes facilitate the subsequent segregation of MSP to budding spermatids and away from central residual bodies. Here we identify SPE-55 as a key FB assembly factor.
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