1 Introduction Cancer remains one of the most difficult-to-treat human diseases, with traditional therapeutic modalities such as surgery, chemotherapy, and radiation often failing to offer complete cures.[1-3] Recent advancements in immunotherapy, including various vaccination strategies, have opened new avenues for promoting durable antitumor responses.[4, 5] In terms of vaccine design, nanoparticulate platforms offer a number of distinct advantages that help to boost antigen-specific immune...