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Nitanta Garag

As seen in: BioRxiv
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Articles

Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease

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By Katherine Fleck, Victor Luria, Nitanta Garag, Amir Karger
| BioRxiv
Abstract Genome organization is intricately tied to regulating genes and associated cell fate decisions. Here, we examine the positioning and functional significance of human genes, grouped by their lineage restriction level, within the 3D organization of the genome. We reveal that genes of different lineage restriction levels have distinct positioning relationships with both domains and loop anchors, and remarkably consistent relationships with boundaries across cell types.
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Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease

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By Victor Luria, Amir Karger, Katherine Fleck, Nitanta Garag
| BioRxiv
Abstract Genome organization is intricately tied to regulating genes and associated cell fate decisions. In this study, we examine the positioning and functional significance of human genes, grouped by their evolutionary age, within the 3D organization of the genome. We reveal that genes of different evolutionary origin have distinct positioning relationships with both domains and loop anchors, and remarkably consistent relationships with boundaries across cell types.
Open in Who Shared Issue with article?
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