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Nithisha L. Bastin on Muck Rack

Nithisha L. Bastin

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Articles

Integrating machine learning and structure-based simulations to prioritise Z4P as a mutation-resilient IRE1α inhibitor for breast cancer

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By Baranitharan Ethiraj, Rajkumar Sivanraju, Nithisha L. Bastin, P. K. Praveen Kumar, Ravikumar Rajarathinam, J. Shrihari
| Nature Verified
Abstract Breast cancer is one of the most prevalent and lethal malignancies affecting women globally. The increasing resistance to current therapeutic strategies highlights the need for novel molecular targets. Inositol-requiring enzyme 1 alpha (IRE1α), a key sensor in the unfolded protein response (UPR), has emerged as a promising therapeutic target due to its role in tumour progression and survival.
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