Nithya Miriam Abraham

Abstract Heterozygous familial hypercholesterolemia (FH), a monogenic cause for premature coronary artery disease (CAD) is often underdiagnosed. In individuals who meet the FH diagnostic criteria and lack pathogenic variants, polygenic factors are recognized as potential contributors. This study aimed to characterize the spectrum of genetic variants and determine the low-density lipoprotein polygenic risk score (LDL-PRS) among clinically diagnosed FH participants from South India.

I met a kind old lady today. I didn’t ask for her name — I wish I had. But her identity couldn’t be contained in a name. It was in her smile, in the way her eyes lit up, in her warmth, and in the way she spoke to strangers. She was born and raised in Chicago, but now she lives in the suburbs. She has two daughters — one in New Mexico, and another in a place I can’t quite recall the name of. During our conversation, her daughter video called her, and she introduced me as a new friend.