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Nitish Jangde

As seen in: BioRxiv
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Articles

RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

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By Nagi G. Ayad, Mi Hye Lee, Luz Marina Ruiz, Nitish Jangde
| BioRxiv
Abstract Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Current therapies are ineffective for targeting proliferation, leptomeningeal migration, and metastasis of MB cancer cells to visceral organs and therefore, novel treatments are needed. The small GTPase, RAC1, has emerged as an important regulator of actin cytoskeletal dynamics, proliferation, and migration in several cancers.
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