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Niying Zhao on Muck Rack

Niying Zhao

As seen in: Nature
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Articles

Coordinated DNA 5-mC and RNA m 5 C methylation epigenetically regulates MZF1 splice variants to drive EGFR-TKI resistance

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By Huan Zhang, Yutong Pang, Bin Liu, Dongfeng Wang, Xiaojue Wang, Panjian Wei, Jie Lin, Niying Zhao, Shuye Lin
| Nature Verified
Abstract Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) severely limits clinical efficacy. Myeloid zinc finger 1 (MZF1) inhibited EGFR phosphorylation and internalization by maintaining zinc homeostasis, which suggested its potential as a therapeutic target for resensitization. The two MZF1 splice variants exhibited functional divergence. MZF1S demonstrated significantly reduced Zn2+-binding capacity compared with MZF1L owing to C2H2 domain deletion.
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