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Abstract Synaptome architecture describes the spatiotemporal distribution of highly diverse excitatory synapses throughout the brain. Whether and how this architecture is impacted by experience and sensory input is unknown. We found that environmental enrichment and monocular visual deprivation drive large-scale reconfiguration of excitatory synapse populations in more than one hundred regions of the mouse brain.
Introduction Neuronal metabotropic glutamate receptors Group I (mGluRIs) are classically viewed as the modulators (predominantly augmentative) of NMDA receptors (NMDARs); G-protein signaling cascades are the transfer mechanism of this modulation (Rossi et al., 1996; Kunishima et al., 2000; Pin and Acher, 2002). This signaling mechanism can be interrupted by blocking various stages of the G-protein cascade.
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