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Noemi Anna Pesce on Muck Rack

Noemi Anna Pesce

As seen in: Nature
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Articles

Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia

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By Francesco Vallone, Elodie Viry, Ilenia Sana, Alessia Morabito, Matteo Rovere, Nadia Bertola, Silvia Ravera, Samir Mouhssine, Marta Muzio, Paolo Ghia, Candida Vitale, Marta Coscia, Gianluca Gaidano, John Allan, Richard Furman, Tiziana Vaisitti, Silvia Deaglio, Amelia Fascì, Nahal Nabelsi, Silvia Seghezzi, Noemi Anna Pesce, Chloé Duculty, Etienne Moussay, Jerome Paggetti
| Nature Verified
Abstract Mutations in NOTCH1, which occur in ~10% of Chronic Lymphocytic Leukemia (CLL) patients at diagnosis, are typically associated with unmutated (UM) B-cell receptor (BCR) subsets and define patients with earlier treatment need. Using primary CLL cells classified as NOTCH1 wild-type (CLL/NWT) or mutated (CLL/NM), both with UM-BCR, we show that BCR stimulation activates the NOTCH1 pathway, upregulating metabolic programs and mitochondrial biogenesis, selectively in CLL/NM.
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