Noga Fuchs Weizman

Abstract Cannabis consumption and legalization is increasing globally, raising concerns about its impact on fertility. In humans, we previously demonstrated that tetrahydrocannabinol (THC) and its metabolites reach the ovarian follicle. An extensive body of literature describes THC’s impact on sperm, however no such studies have determined its effects on the oocyte. Herein, we investigate the impact of THC on human female fertility through both a clinical and in vitro analysis.

ABSTRACT Research question Can the adipo-cytokine milieu of the follicular niche improve our ability to predict treatment outcomes in infertile patients? Design Follicular fluid samples from overweight patients were analyzed and compared with samples from matched normal-weight patients.

To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 Flowchart depicting the number of patients recruited, cumulus-oocyte complexes (COCs) collected, and exclusion and inclusion processes applied, leading to the final cohort included in the analysis. Figure 2 Principal component analysis (PCA) plot depicting the clustering of samples based on responder type (Black – High, White – Normal, and Orange – Poor).