Nolan Tucker

Abstract After 170 years of searching, scientists finally know what the head of the largest known arthropod Arthropleura looked like, unlocking the key to its affinities. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Of all the creatures that once inhabited our planet, large arthropods are viewed with macabre fascination as eerie, almost otherworldly beings.

Abstract While cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to treatment. Here, we report an unexpected role for the transcription factor p63 (Trp63/TP63) in the fate choice of the squamous versus neuroendocrine lineage in esophageal development and malignancy.

Abstract Oxidative weathering of sulfide minerals in sedimentary rocks releases carbon dioxide (CO2) into the atmosphere. In permafrost zones, this could be a positive feedback on climate change if it increases with warming, yet sulfide oxidation rates and their temperature response remain unknown over large spatial and temporal scales. We analyze a 60-year sulfate concentration dataset from catchments across the Mackenzie River Basin.