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Nombuso Yende

As seen in: medRxiv
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A Nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosing

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By Renu Verma, Neesha Rockwood, Roeland Wasmann, Nombuso Yende
| medRxiv
Abstract Rationale Standardized dosing of anti-tubercular (TB) drugs leads to variable plasma drug levels, which are associated with adverse drug reactions, delayed treatment response, and relapse. Mutations in genes affecting drug metabolism explain considerable interindividual pharmacokinetic variability; however, pharmacogenomic (PGx) assays that predict metabolism of anti-TB drugs have been lacking.
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