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Nomcebo Msthali on Muck Rack

Nomcebo Msthali

As seen in: BioRxiv
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Articles

HIV-1 subtype C LTR Sp1IIIT5A mutant enhances transcription activity and Sp1 binding affinity

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By Ibrahim O. Kehinde, Rene B. Khan, Mahmoud E. Soliman, Nomcebo Msthali
| BioRxiv
Abstract Background: Genetic variation within HIV-1 subtype C (HIV-1C) long terminal repeat (LTR) transmitted/founder viruses influences transcription activation and clinical disease outcomes. The role of specific mutations such as thymine-to-adenine (T5A) mutation at position five of the Specificity protein 1 (Sp1) III motif (Sp1IIIT5A) remains underexplored. This study investigates the impact of Sp1IIIT5A on HIV-1C LTR transcription activity and Sp1 binding affinity.
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