Noncoding RNA Laboratory

1 Introduction The ability of cancer cells to adapt to and resist various stimuli is crucial for their survival in changing environments [1, 2]. Cancer cells commonly respond to harsh conditions by rearranging cellular structures and reprogramming gene expression. In this endeavour, cellular compartmentalisation via membranes and proteins enables the execution of cellular responses within specific microenvironments.

1 INTRODUCTION The endoplasmic reticulum (ER), long underestimated, plays crucial roles in cellular function, including protein synthesis, folding, transportation and storage of calcium, lipids, glycoproteins and steroids.1 The ER's dynamic structure and interconnectedness with other organelles, like the Golgi apparatus and mitochondria, facilitate its multifaceted functions.2 Despite its significance, the ER is susceptible to stressors such as chemical insults, disruptions in cellular...