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Anti-CD19 CAR T cells for pediatric patients with treatment-refractory autoimmune diseases - Nature Medicine
Abstract Chimeric antigen receptor (CAR) T cell therapy was recently proposed as a treatment for adults with B-cell-mediated autoimmune diseases (ADs) refractory to conventional immunomodulatory therapy.
Free-breathing phase-resolved functional lung (PREFUL) low-field magnetic resonance imaging (LF-MRI) of pulmonary dysfunction after surviving childhood cancer | Communications Medicine
Abstract Childhood cancer survivors have a high risk of chronic multi-organ disease that does not plateau over time. To date, there is a lack of sensitive diagnostic techniques that allow early detection of tissue damage before clinical symptoms occur, particularly regarding pulmonary function.
Detection of signature double‐negative T cells is a predictive marker to identify autoimmune lymphoproliferative syndrome associated with FAS loss of function
To the Editor: The autoimmune lymphoproliferative syndrome (ALPS) is caused by defects in the FAS-dependent apoptosis leading to chronic lymphoproliferation, autoimmunity, chronic multilineage cytopenia, an increased risk for developing B cell lymphomas, and a characteristic accumulation of CD4/CD8-negative, T-cell receptor (TCR), αβ-positive T-cells (double-negative, DNT-cells).1, 2 The heterogeneous clinical phenotype of ALPS patients and overlap with similar diseases like CTLA-4 and LRBA...
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