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Articles by Norbert Frey
Association of PROMIS Profile-29 based quality of life with heart failure in asymptomatic patients (HERZCHECK)
Abstract Heart failure is often diagnosed only when symptoms become acute, but early detection could help prevent disease progression. As patient-reported quality of life is strongly associated with heart failure outcomes, it may also serve as an additional correlate with the disease before symptoms occur. This cross-sectional study investigates the associations of quality of life and asymptomatic heart failure and was conducted as an exploratory, hypothesis-generating analysis.
HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity
Abstract Anthracycline-induced cardiotoxicity remains a major limitation of cancer therapy, and effective preventive strategies are lacking. Topoisomerase IIb has been implicated as a central driver of this toxicity, suggesting that epigenetic regulators may interfere with the pathological cardiac response.
Visual prompt engineering for multimodal and irregularly sampled medical data
Abstract A patient undergoes multiple examinations in each hospital stay, where each provides different facets of the health status. These assessments include temporal data with varying sampling rates, discrete single-point measurements, therapeutic interventions such as medication administration, and images. While physicians are able to process and integrate diverse modalities intuitively, neural networks need specific modeling for each modality complicating the training procedure.
Dual antithrombotic therapy using potent antiplatelet inhibitors in atrial fibrillation and acute coronary syndrome: a randomized controlled trial
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Abstract The selection of the optimal antithrombotic regimen in patients with atrial fibrillation and acute coronary syndrome remains challenging. Previous trials have demonstrated that dual antithrombotic therapy (DAT), consisting of direct oral anticoagulants (DOACs) plus a P2Y12 inhibitor, reduces bleeding compared to a triple-therapy regimen using vitamin K antagonists.
By Konstantinos D. Rizas, Konstantinos Mourouzis, Dominik Rath, Christoph B. Olivier, Theofanis Korovesis, Amin Polzin, Amani Al Tawil, Reza Wakili, Katharina Mayer, Sarah Lang, Sebastian Maier, Lorenz Bott-Flügel, Harilaos Bogossian, Konstantinos E Iliodromitis, Julius Steffen, Elodie Eiffener, Lauren Sams Verified, Tobias Petzold, Axel Linke, Felix M. Heidrich, Saif Zako, Andreas Schäfer, Frank Edelmann, David Leistner, Fabian Knebel, Georg Nickenig, Blerim Luani, Tienush Rassaf, Hüseyin Ince Verified, Ibrahim Akin, Micha T. Maeder, Meinrad Gawaz, Hans-Josef Feistritzer, Norbert Frey, Stefan Kääb, Matthias Pauschinger, Thomas Stiermaier, Ingo Eitel, Jan Wolter, Michael Schreinlechner, Axel Bauer, Christoph Stellbrink, Ulf Landmesser, Paulus Kirchhof, Dirk Sibbing, Holger Thiele, Adnan Kastrati, Ulrich Mansmann, Steffen Massberg, Lukas von Stuelpnagel, Marion Janisch, Tanja Ulrich, Florian Brattinger, Luisa Freyer, Samuel Sossala, Nikolaos Dagkonakis, Mariya Maslarska, Riza Sahin, Marc Kollum
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Nature
Verified
Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases
Abstract Cellular protein homeostasis, or proteostasis, underpins the integrity, adaptability, and survival of all cells by balancing protein synthesis, folding, trafficking, and degradation. This multilayered network is sustained by coordinated actions of molecular chaperones, the ubiquitin‒proteasome system, autophagy-lysosomal pathways, and organelle-specific quality control programs.
Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure - Nature Communications
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Abstract Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identify elevated Ser396/Ser398 phosphorylation of the type I interferon (IFN) response regulating transcription factor IRF3 in the myocardium of patients and male mice with ischemic cardiomyopathy.
By Manju Kumari, Ioannis Evangelakos, Anushka Deshpande, Roberto Carlos Frias-Soler, Glynis Klinke, Hyun Cheol Roh, Luisa Lange, Michael A. Berlin, Marceline M. Fuh, Tian Tian, Carolin Lerchenmüller, Marc Freichel, Almut Schulze, Viacheslav O. Nikolaev, Thomas Eschenhagen, Evan Rosen, Ludger Scheja, Ashraf Yusuf Rangrez, Joerg Heeren, Norbert Frey, Kirstie A. De Jong, Nesrin Schmiedel, Nicolàs Palacio-Escat, Adriano de Britto Chaves-Filho, Jakob Johannes Buss
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Nature
Verified
Herzgesundheit darf keine Frage des sozioökonomischen Status sein
Wenn man Herzinfarkte verhindern will, reicht es nicht, nur Cholesterin und Blutdruck zu behandeln, es müssen auch die sozialen Ursachen angegangen werden: Ungleiche Bildungschancen, Arbeitslosigkeit und fehlende Prävention. Wie groß der Einfluss dieser Faktoren ist, zeigt sich im Bundesland Bremen. Hier wurden deshalb gezielte Strategien entwickelt („Bremer Modell“), damit Herzgesundheit keine Frage von Einkommen oder Herkunft bleibt.
Case Report: Right-atrial reverse remodeling causing resolution of new-onset torrential tricuspid regurgitation after successful rhythm control
Abstract In patients with persistent atrial fibrillation, adverse atrial remodeling may induce annular enlargement causing severe mitral- or tricuspid valve regurgitation and heart failure symptoms. Herein, we describe a case of rapidly progressive right atrial (RA) adverse remodeling due to new onset persistent AF, causing tricuspid annular dilatation and torrential tricuspid regurgitation (TR) in a 79-year-old female patient.
Impact of pneumatic tube vs. bicycle courier transport on platelet aggregation: influence of sex and diabetes
Introduction Platelets play a key role in hemostasis and are central to the regulation of bleeding and thrombosis processes (1). Measuring platelet function is therefore crucial for assessing bleeding risk, particularly before surgical procedures or in cases of suspected hemorrhagic disorders (2). Platelet function tests are used to detect congenital or acquired platelet dysfunctions and to monitor the effectiveness of antiplatelet therapy.
In heart failure, echocardiographic parameters of right ventricular function are powerful tools to predict renal failure
Introduction Because the heart supplies the organs and tissues of the body with blood while the kidneys control fluid balance and salt homeostasis, heart failure (HF) often leads to kidney failure.
Guideline update: phenotype-based management of cardiomyopathy
Die Leitlinien bieten aktualisierte Klassifikationen für die dilatierte und nicht dilatierte linksventrikuläre (LV) Kardiomyopathie, wobei besonderer Wert auf die Bedeutung der kardialen Magnetresonanztomografie (CMR: Cardiovascular Magnetic Resonance) zur Beurteilung des Myokards gelegt wird.
Improving the rate of heart failure with improved ejection fraction
Invited Editorial Improving the rate of heart failure with improved ejection fraction Heart failure with improved versus persistently reduced left ventricular ejection fraction: A comparison of the BIOSTAT-CHF (European) study with the ASIAN-HF registry Thong Huy Cao, Wan Ting Tay, Donald J.L. Jones, John G.F. Cleland, Jasper Tromp, Johanna Elisabeth Emmens, Tiew-Hwa Katherine Teng, Chanchal Chandramouli, Oliver Charles Slingsby, Stefan D. Anker, Kenneth Dickstein, Gerasimos Filippatos, Chim C.
Deutsche Medizinische Wochenschrift / Abstract
Die kardioonkologische Leitlinie, veröffentlicht in Zusammenarbeit mit der EHA (Europäische Gesellschaft für Hämatologie), der ESTRO (Europäische Gesellschaft für therapeutische Radiologie und Onkologie) und der ESC (Europäische Gesellschaft für Kardiologie), bietet 272 Empfehlungen zur Risikostratifizierung vor Therapiebeginn, zum Monitoring während der Therapie und zur Behandlung therapieassoziierter kardiovaskulärer Nebenwirkungen.
Cancers | Free Full-Text | Effects of Ionizing Radiation on Cardiac Implantable Electronic Devices (CIEDs) in Patients with Esophageal Cancer Undergoing Radiotherapy: A Pilot Study
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Severe aortic stenosis management in heart valve centres compared with primary/secondary care centres
Abstract Objective Current guidelines recommend use of heart valve centres (HVCs) to deliver optimal quality of care for patients with valve disease but there is no evidence to support this. The hypothesis of this study is that patient care with severe aortic stenosis (AS) will differ in HVCs compared with satellite centres. We aimed to compare the treatment of patients with AS at HVCs (tertiary care hospitals with full access to AS interventions) to satellites (hospitals without such access).
Exploring the Involvement of Gut Microbiota in Cancer Therapy-Induced Cardiotoxicity
Abstract : Trillions of microbes in the human intestinal tract, including bacteria, viruses, fungi, and protozoa, are collectively referred to as the gut microbiome. Recent technological developments have led to a significant increase in our understanding of the human microbiome. It has been discovered that the microbiome affects both health and the progression of diseases, including cancer and heart disease.
Severe aortic stenosis management in heart valve centres compared with primary/secondary care centres
Tanja K Rudolph1, http://orcid.org/0000-0002-6278-5670David Messika-Zeitoun2, Norbert Frey3,4, Matthias Lutz3, Laura Krapf5, Stephanie Passefort6, John Fryearson7, Helen Simpson8, Kai Mortensen9, Sebastian Rehse10, Andreas Tiroke11, Fotini Dodos12, Florian Mies13, Cornelia Deutsch14, Jana Kurucova15, Martin Thoenes16, http://orcid.org/0000-0003-4970-2110Peter Bramlage14, Richard Paul Steeds17 for the IMPULSE enhanced investigators 1Department of Cardiology, Heart and Diabetes Center North...
Letter by Giannitsis et al Regarding Article, “Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T”
Originally publishedhttps://doi.org/10.1161/CIRCULATIONAHA.122.060812Circulation. 2022;146:e202–e203 "Letter by Giannitsis et al Regarding Article, “Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T”." Circulation, 146(15), pp. e202–e203 Footnotes References 1. du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, ; BASEL XII Investigators.
Large Mobile Left Ventricular Thrombi Formation in a 32-Year-Old Despite Direct Oral Anticoagulation With Dabigatran:
Abstract Direct oral anticoagulant agents (DOACs) are widely used in the treatment of arterial and venous thrombi. We report the case of a 32-year-old patient who was receiving permanent DOAC therapy. Despite adequate use, 2 large left ventricular thrombi developed. Surgical thrombectomy was performed. The patient recovered well and received anticoagulation with phenprocoumon thereafter.
SUMO proteins in the cardiovascular system: friend or foe?
Abstract Post-translational modifications (PTMs) are crucial for the adaptation of various signalling pathways to ensure cellular homeostasis and proper adaptation to stress.
Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis
Original research article Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis Free Norbert Frey1, Richard Paul Steeds2, Tanja K Rudolph3, Jeetendra Thambyrajah4, Antonio Serra5, Eberhard Schulz6, Jiri Maly7, Marco Aiello8, Guy Lloyd9, Alessandro Santo Bortone10, Karl Eugen Hauptmann11, Alberto Clerici12, Georg Delle Karth13, Johannes Rieber14, Ciro Indorfi15, Massimo Mancone16, Loic Belle17, Alexander Lauten18, Martin Arnold19, Berto J Bouma20,...
Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis
Original research article Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis Norbert Frey1, Richard Paul Steeds2, Tanja K Rudolph3, Jeetendra Thambyrajah4, Antonio Serra5, Eberhard Schulz6, Jiri Maly7, Marco Aiello8, Guy Lloyd9, Alessandro Santo Bortone10, Karl Eugen Hauptmann11, Alberto Clerici12, Georg Delle Karth13, Johannes Rieber14, Ciro Indorfi15, Massimo Mancone16, Loic Belle17, Alexander Lauten18, Martin Arnold19, Berto J Bouma20,...
Left Ventricular Biopsy in the Diagnosis of Myocardial Diseases
Myocardial biopsies have been performed as early as 1956, initially via transthoracic needle, and in 1962 for the first time in a transvenous approach. A consensus statement of the American Heart Association, American College of Cardiology, and European Society of Cardiology endorsed the acquisition of biopsies in several clinical scenarios in which biopsy-guided diagnostics can identify a treatable specific cause.
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