Noria Alta s

Defence mechanisms are fundamental to the survival of all organisms, from the most primitive prokaryotic cells to complex vertebrates. These mechanisms have evolved to protect organisms from biotic and abiotic stress, ensuring their continued existence and success. Organisms constantly monitor their environment and possess mechanisms that enable them to “remember” recent challenges, allowing for more effective responses to future threats [1].

Computational study of polyhomologation: understanding reactivity with B, Al, and Ga† In the polyhomologation (PH) reaction, boron reagents (BR3, where R = alkyl) react with Corey's ylide (H2C−S+(O)(CH3)2) to achieve methylene insertions into carbon–boron bonds. The reaction mechanism begins with the formation of an ate complex, driven by the interaction between the electron pair of the methylide and the vacant p orbital of the initiator (BR3).

Ultrasound-assisted diastereoselective green synthesis of spiro-fused-γ-lactams functionalized with an amide bond heterocyclic bioisostere via the Ugi azide/domino process coupled strategy† A series of linked-type 1,5-disubstituted tetrazoles (1,5-DS-Ts) were synthesised via an isocyanide-based multicomponent reaction (IMCR) and used as synthetic platforms to access bound-type polyheterocycles containing an epoxyisoindol-1(6H)-one scaffold under green conditions.