Noula Shembade on Muck Rack

Noula Shembade

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Articles

Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy - Nature Communications

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By Suchitra Mohanty Verified, Irene E. Reider, Jesse White Verified, Sarah McCormick, Sarah Mccormick, Christopher C. Norbury, Edward W. Harhaj, Sujit Suklabaidya, Dominic Colter, Noula Shembade
| Nature Verified
Abstract The cGAS-STING pathway is a critical regulator of type I Interferon (IFN) and inflammation upon cytosolic DNA-sensing. cGAS-STING signaling termination is regulated by lysosomal-mediated degradation of STING; however, the mechanisms controlling the inhibitory targeting of STING are incompletely understood. Here, we identify the selective autophagy receptor TAX1BP1 as a negative regulator of the cGAS-STING pathway.
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