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Noy Gamliel on Muck Rack

Noy Gamliel

As seen in: BioRxiv
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Articles

Cdk1 and PP2A constitute a molecular switch controlling orderly degradation of atypical E2Fs

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By Danit Wasserman, Sapir Nachum-Raines, Noy Gamliel, Nasrin Qassem
| BioRxiv
Abstract Dynamic oscillations in the phosphorylation and ubiquitination of key proliferative regulators are defining features of the eukaryotic cell cycle. Resetting the cell cycle at the mitosis-to-G1 transition requires activation of the E3 ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C), which ensures cell cycle irreversibility by targeting dozens of substrates for degradation, safeguarding genome integrity.
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