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Nuo-Xi Zhang on Muck Rack

Nuo-Xi Zhang

As seen in: Nature, Wiley Online Library
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Articles

Neuroprotective effect of astrocytic dopamine Drd2 receptor on mitochondrial complex I in a mouse model of Parkinson’s disease through β-arrestin2-NDUFA10 regulation

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By Nuo-Xi Zhang, Juan-juan Guo, Chun-Yan Fan, Jian-Hua Ding, Yao Wei, Yang Liu Verified, Gang Hu, Qian-Hui Huang
| Nature Verified
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disease. Current treatment strategies for PD mainly focus on dopamine replacement and regulation of dopaminergic signaling. Here, we reveal the unique role of the astrocytic dopamine D2 (Drd2) receptor in regulating mitochondrial function, thereby improving Parkinson’s disease-like symptoms in a mouse model.
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Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

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By Rong-Xin Zhu, Ting-Ting Sun, Yue-Han Chen, Nuo-Xi Zhang
| Wiley Online Library Verified
1 Introduction Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons of the Substantia nigra pars compacta (SNpc).[1] Current evidence strongly suggests that PD results from complex interactions among genetic predisposition, environmental exposures, the misfolding and aggregation of α-synuclein, mitochondrial impairment, oxidative stress, neuroinflammatory processes, and aberrant immune responses.[2] However, the...
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