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Abstract We present a WBT Atlas, comprising 4444 WBT samples across 98 distinct health conditions, enabling systematic exploration of disease-associated transcriptomic signatures. Health condition–specific profiles are characterized across immune, metabolic, and cell-type specific features at the gene, gene module, and pathway levels.
HIGHLIGHTS • Biotinidase deficiency should be considered in the differential diagnosis of seronegative NMOSD. • Regularly biotin supplementation is important in biotidinase deficiency. • Central nervous system involvement may be fatal in patients with biotinidase deficiency.
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