Skip To Main Content
Nyakuoy Yak on Muck Rack

Nyakuoy Yak

As seen in: BioRxiv
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Nyakuoy

Contact Nyakuoy, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum

|
By Mohammed R. Shaker, Julian Sng, Nyakuoy Yak, Sean Morrison
| BioRxiv
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, remains a global health concern despite vaccines, neutralizing antibodies, and antiviral drugs. Emerging mutations can reduce the effectiveness of these treatments, suggesting that targeting host cell factors may be a valuable alternative.
Open in Who Shared Issue with article?

DDHD2 provides a critical flux of saturated fatty acids to support neuronal energy demands

|
By Nyakuoy Yak, Tobias Binder, Siyuan Lu, Liidia Koludarova
| BioRxiv
Abstract Mitochondrial ATP production is fuelled by a fatty acid flux generated by phospholipase and triglyceride lipases in metabolically demanding tissues such as heart and liver, while the brain has long been believed to use almost solely glucose for energy. Phospholipase A1 enzyme DDHD2 is a major triglyceride lipase in the brain, and the loss of DDHD2 function results in a saturated free fatty acid (sFFA) imbalance and lipid droplet (LD) accumulation in the brain.
Open in Who Shared Issue with article?

Saturated fatty acid-Coenzyme A supplementation restores neuronal energy levels and protein homeostasis in hereditary spastic paraplegia

|
By Nyakuoy Yak, Siyuan Lu, Tobias Binder, Reshinthine Purushothaman
| BioRxiv
Abstract Hereditary Spastic Paraplegia (HSP) type 54 is a complex childhood autosomal recessive neurodegenerative disorder characterized by impairments in both neuromuscular and cognitive functions. This condition arises from mutations in the DDHD2 gene, which encodes for the phospholipase A1 enzyme DDHD2.
Open in Who Shared Issue with article?
See all 4 articles