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Articles by O. Johnson
3:45 PM Abstract No. 195 Leveraging transarterial chemoembolization-induced metabolic reprogramming and CRISPR-based genome editing to identify latent tumor viability with DNP-13C-NMRS in hepatocellular carcinoma - Journal of Vascular and Interventional R
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Transarterial chemoembolization (TACE) is used to treat advanced hepatocellular carcinoma (HCC). By restricting a tumor’s arterial supply, TACE facilitates local reduction in oxygen and nutrients. While TACE slows disease progression, recurrence occurs in the majority of cases.
Abstract No. 693 CRISPR-based genome editing identifies metabolic dependencies of a biopsy-derived hepatocellular carcinoma cell line, enabling targeted therapy selection and response evaluation
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Hepatocellular carcinoma (HCC), the fastest rising cause of cancer death in the United States, has few treatment options for advanced disease. Recognizing the heterogeneity of HCC, we hypothesized that CRISPR-based screening of metabolic dependencies in HCC cells derived directly from percutaneous biopsies would enable targeted therapy selection.
PASTOR’S CORNER: A skeptic by nature
I am a skeptic. Yes I admit it. But, my skepticism does not mean unbelief. It simply means I’m not sure of the validity of some of the Bible teachings I have heard over the years. When something rubs me the wrong way, my natural inclination is to go to the scriptures in an effort to discover the basis for the teaching in question. Here’s a case in point.
PASTOR’S CORNER: God’s law and the law of the land
Before putting pen to paper, I felt this topic of discussion may not be a popular one because it may collide with the current political and emotional climate in today’s society. In spite of the risk, we’re going to push through and address our law of the land. But first, let me begin with a confession; I am not an attorney, neither have I attended law school. My only claim is 20 years of service to the citizens of Los Angeles as a field cop before retirement.
PASTOR’S CORNER: Setting the record straight on eating pork
I hate to burst the bubbles that people have blown up for themselves, but when those bubbles contain scriptural misconceptions, I feel compelled to speak up. Here’s one bubble many of us have kept afloat for years: pork is a no-no for the people of God. The bubble is supported by the Old Testament dietary law found in Leviticus 11:7, 8.
PASTOR’S CORNER: A word to the wise is sufficient
Let’s do another “mini-Bible study� with this article, just to add a bit of variety to the column. I’m sure you are familiar with this sentiment: “I will never leave thee, nor forsake thee.� We have been taught to receive this as a promise from God exclusively to his people throughout all of time. If this is true, then the scriptures should contain this exact quote directly from him. So, let’s check it out to see if we are scripturally justified in our belief.
PASTOR’S CORNER: Prosperity in the sight of God
In this life, there are two ways to obtain the desires of your heart – the world’s way and God’s way. You have probably guessed by now that the way of the world is far inferior to God’s way. There are multiple reasons why: the world’s way is lust–driven, highly competitive and ultimately leads to conflict and violence, as we fight with one another for what we want.
PASTOR’S CORNER: What is your eternal destination?
Any Facebook enthusiast is familiar with this question; it’s the first thing you see at the top of the first page of the news feed. Scrolling down from that first page is where everybody shares what’s on their minds. I’m always amazed at some of the stuff people admit they’re thinking about. Nothing seems to be off limits. I won’t bore you with some of the idiotic posts I’ve seen, but I am grateful that once in a while I run across a post about the goodness of God.
PASTOR’S CORNER: God and our political climate
I’ve never been a political junkie. In fact, I’ve always considered politics kind of boring — until now. The current White House occupants changed all that with their emphasis on name-calling, disrespect and downright ignorant rantings. This is an era in American politics we have never seen before, and hopefully will never see again. But before it disappears, I have major concerns to discuss.
PASTOR’S CORNER: Creating a pyramid for change
“I’m sick and tired of you chu’ch folks!” Noooo! This does not describe my thoughts about those of us who regularly attend Sunday church services. This is the first line of a rap piece written and recorded by a very talented, articulate young black man named Landa Gherra. He raps at length about “chu’ch folks”, but he is very clear about to whom he is referring.
PASTOR’S CORNER: Which category do you fall in?
Jesus must be disappointed! I say this because many professing Christians have fallen far below his expectations. Over the years, since his ascension, we have succeeded in changing his church from the unified church he built into the fragmented, disjointed organization it is today. And, the prognosis for improvement seems rather dim. After 48 years of observing Christians inside and outside the church building, I have concluded that each of us can be assigned to one of four major categories.
PASTOR'S CORNER: The power of a winning attitude
Motivational speakers will tell you that developing and maintaining a winning attitude are big factors in being successful in life’s endeavors.
PASTOR'S CORNER: Becoming our harshest critic
It seems to be fashionable these days to engage in what the younger set calls “body-shaming.” As I understand it, you have been body-shamed when someone criticizes anything about your physical appearance that they deem to be unattractive. Maybe your eyes are too far apart, or too close together; your nose is too big, or too small; I think you get the picture. More often than not, those critics are comparing you with all those perfect images we see in television and magazine ads.
PASTOR’S CORNER: Don’t let the gray hair fool you
Reaching senior citizen status can be a blessing or a curse, depending on the culture in which one lives. In Asian cultures, it’s a pretty good deal. China has an Elderly Rights Law, which mandates that the offspring of elderly parents must routinely visit them. There are no excuses; distance is not an issue; failure to comply can mean paying a fine or jail time. On the Korean peninsula, role reversal is common practice.
PASTOR’S CORNER: A prescription for prayer
When you ask God in prayer for a specific blessing, do you always receive what you ask for? If your answer is in the negative, don’t feel lonely. I can’t honestly give an affirmative answer to the question, neither do I know anyone who can. But here’s another question for you: would you like to always give a yes to the first question? If you would, then read on. Jesus teaches us how to achieve success in our prayer lives in Matthew 17:19, 20.
PASTOR’S CORNER: The power of God’s word
I am a living witness that if one is serious about studying the word of God, he or she will experience a total change, for the better, of attitude, speech and behavior. The word has that effect on the serious student; but, I have discovered that, the word can have a similar impact on the not-so-serious, intermittent church-goer. I recently heard about a man who wrote a letter to the editor of his local newspaper.
PASTOR’S CORNER: What happens when people backslide
I suspect that many of us are suffering from an age-old malady that had its origin during the exodus when God saved his people from Egyptian bondage. When we study the history of God’s people from then until now, it’s painfully obvious that the malady still lingers. The disease we’re referring to is commonly called backsliding. We find the word first used in scripture in Jeremiah 3:6 and a few verses that follow.
PASTOR’S CORNER: How to become a better person
Here’s the question for the day: do you want to be a better person? I hope you are not one of those perfect people who believe you cannot possibly be any better than you already are. If you believe that, then there’s no room for you to grow in life. But, if you’re in tune with the real you, you are aware that there’s room for improvement. That’s our focus today: self- improvement. For many of us, self-improvement translates into weight loss.
PASTOR’S CORNER: The ministry of reconciliation
Those who have been called to teach and preach the Gospel of Christ will, at some point, report that “salvation is free.” I think we can all agree that this is a scriptural truth before the fact of salvation. Scripture is clear that no one is required to pay or do anything to be saved; but, the story changes after the fact.
The Coeur d'Alene Press
SPIRIT LAKE — The Timberlake Tigers high school girls basketball team is a tight group of talented players. The defending state 3A and Intermountain League champions are gunning for another title, an opportunity that seems to come with regularity for coach Matt Miller’s teams. They’ve been in the state title game all but once since 2011, finally winning the entire thing in 2016. So what’s so special about this group? Well for one, they don’t brag about routing other teams with regularity.
PASTOR’S CORNER: The Christian approach to leadership
If you are in a church in the middle of searching for a new pastor, or a new pastor searching your membership for leaders, this article is for you. Scripture gives us an approach to finding leaders before the fact, which provides a better chance of matching the right people to the right jobs. Our focus here is in the church, but the approach works just as well in the corporate world.
PASTOR’S CORNER: What does that scripture mean?
What does that mean? If you are a Bible reader, novice or student, you have probably asked yourself that question many times, as I have. The answer to the question can be a long drawn out process depending on the scripture in question. Space will not allow a comprehensive answer here, but as a start, Jesus puts us on the right road in his parable of the sower, Luke 8:4-18.
PASTOR’S CORNER: Becoming scripturally savvy
In case you missed October’s article, we talked about the why of church attendance, which involves preparing ourselves before we get there so we can receive the benefits of our attendance. Two benefits were mentioned, spiritual edification and knowledge of the word of God. Today, we want to elaborate on those, both of which come from the preached word. In my view, preaching time is the highlight of the church service.
PASTOR’S CORNER: The influence of affluence
In today’s society, we spend a good percentage of our time pursuing money and other material things so we can live the so-called good life, the American Dream. Some of us become so engrossed in this pursuit that we lose sight of the influence it has on our thinking, our values and our behavior. Admit it or not, we are very often influenced by the affluence that surrounds us. We admire that shiny new car in our neighbor’s driveway, dreaming of the day we can have one in our driveway.
PASTOR’S CORNER: Why should you go to church?
Sometimes I think there should be a class, call it Church 101, that all of us are required to attend before we set foot in any given Christian church. Why? Because I believe most of us go for the wrong reasons: to find a mate (boyfriend or girlfriend, husband and wife); to socialize with folks we haven’t seen in a week; to see and be seen; to entertain or be entertained, ad infinitum.
PASTOR’S CORNER: Deciding who to place your trust in
It’s often said that life is a long series of decisions. There’s a lot of truth in that observation. We are inundated with decisions every second of every day; when to go to bed every night; when to get up every morning; what to wear each day; where and what to eat every day. But that’s life and we just have to live with it.
PASTOR’S CORNER: Giving God’s way
Let’s be clear at the beginning: this is not an attempt to convince anyone to give more money to his or her local church. Unfortunately, the mere mention of money in most churches usually results in silence and tension in the sanctuary. That is not the goal here. My purpose is to explore giving in a general sense and as a major tenet of the Christian faith. Giving holds a major place in the lives of Christians because the gospel began with giving.
PASTOR'S CORNER: Life’s true purpose
One’s purpose in life is a topic I’ve heard discussed on numerous occasions on Christian television. Various theories have been offered on this issue such as whatever you have a passion for; or, what you do better than anyone else. Describing purpose in those terms overlooks one important necessary element in the idea of purpose. In deciding your life purpose, the element of a desired end, result or goal must be included. So purposewithout a goal to accomplish is not a purpose.
PASTOR’S CORNER: Indifference may be a spiritual problem
Once in a while, most of us find ourselves in situations which elicit responses like “so what?” or “who cares?” or “what’s the difference?” These can be perfectly legitimate responses if the situation is of no consequence to the respondent. If, however, one finds himself uttering those types of questions in excess, they could be symptoms of a deeper, spiritual problem. The problem we refer to is an attitude — a spirit of indifference — which can be a killer if one doesn’t evict it from the mind.
PASTOR’S CORNER: Learning to resist temptation
The late Flip Wilson’s character “Geraldine” was mistaken when she proclaimed that “the devil made me do it!” We can’t blame our indiscretions on him; we transgress against God because we choose to do so, not because we’re led by the devil. The devil does however have a role in our decisions to act contrary to the will of God. In 1 Thessalonians 3:5, Paul refers to the devil as “the tempter” which gives us a clue as to his role. All he does is supply the opportunity and we do the rest.
PASTOR’S CORNER: Live your life on purpose
If you find yourself setting goals that are never achieved, you probably are the victim of the nemesis of achievement – better known as procrastination. It has delayed, and even ruined, the goals and dreams of more people than anything else in human life. I know of where I speak, because I was a longtime victim – not for days, weeks or months, but literally for years. Many years ago I promised myself that I would sit down and start reading the Bible.
PASTOR'S CORNER: Let God’s light shine
If you are a Christian, you have the distinction of being among the most scrutinized group of people on Earth. Some Christians may see this as a negative and might object to being under a microscope. But students of scripture know that this scrutiny is God’s will for the believer. Jesus says so in Matthew 5:14, 16, where he tells us that we are the light of the world and encourages us to let our lights shine so that all can see that we are his disciples.
PASTOR'S CORNER: God’s awesome pledge
All that glitters is not gold.” Sound familiar? It should, because it’s a pearl of wisdom offered over the ages to teach us that everything that’s good to us may not be good for us. And there’s biblical evidence for its truth from the pen of Solomon in Proverbs 14:12.
PASTOR'S CORNER: The danger of overindulgence
As most believers know, Biblical scripture can be rewarding, fulfilling and eminently nourishing from a spiritual standpoint – but it also can be challenging to absorb and tough to understand. That’s why we’re going to conduct what might be described as a “mini-Bible study” right here, right now. I’ve recently re-read two very similar verses that, up to now, have been especially challenging to me.
PASTOR'S CORNER: The challenge of conscience
I have heard it said that life amounts to a series of thousands of decisions. When I think back on my own life, I have to agree. Most of us struggle at some point when it comes to decision-making in life. Which job should I apply for? What should I wear to that important function I want to attend? Which college is best for me? The questions and decisions go on and on throughout our lives. We usually turn to family and friends when faced with tough decisions.
Solano Coalition for Better Health: Excuses can be a good thing in improving health
Last May, when Abby Pell, 33, fitness competitor and nutritionist posted an Instagram photo of her six-pack abdomen next to her gaping daughter, with the caption “I have a Kid. A Six Pack.
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