Odessa Van Goethem on Muck Rack

Odessa Van Goethem

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Articles

Saccharomyces cerevisiae reduces vulvovaginal candidiasis severity through modulation of fungal pathogenicity and inflammatory responses

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By Mart Sillen, Silke Baldewijns, Ilse Palmans, Greetje Vande Velde, Nele Berghmans, Mieke Gouwy, Lies De Groef, Axel Dietschmann, Paul Vandecruys, Sarah Lebeer, Liesbeth Demuyser, Mark S. Gresnigt, Patrick Van Dijck, Dania El Abyad, Nina Vreys, Odessa Van Goethem, Dolly E. Montaño, Agustin R. Sharpe
| Nature Verified
Abstract Vulvovaginal candidiasis (VVC) affects millions of women globally and is characterized by multifactorial immunopathology, with Candida albicans virulence driving disease progression through epithelial tissue damage and neutrophil hyperactivation and dysfunction contributing to disease severity. Here, we explored the multifaceted nature of S. cerevisiae as a live-biotherapeutic to attenuate C. albicans virulence and modulate host immune responses during VVC. We identified an S.
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