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Oduduabasi Isaiah on Muck Rack

Oduduabasi Isaiah

As seen in: Nature
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Articles

Patient-derived model capturing hypoxia and extracellular matrix remodelling of immunologically cold high-grade serous tumours

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By Simona Plesselova, Hailey Axemaker, Kristin Calar, Jared Wollman, Somshuvra Bhattacharya, Etienne Z. Gnimpieba, Congzhou Wang, Hiruni K. Sumanasiri, Kristina W. Thiel, Maria Bell, Oduduabasi Isaiah, Darci M. Fink, Pilar de la Puente
| Nature Verified
Abstract High-grade serous carcinoma tumours present poor survival rates, often associated with immunologically excluded environments driven by hypoxia and extensive extracellular matrix remodelling that disrupt tumour-stromal-immune interactions. Current experimental models fail to fully capture these microenvironmental features, limiting understanding of tumour-immune dynamics and drug development.
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