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Olateju O. Storment on Muck Rack

Olateju O. Storment

As seen in: Nature
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Articles

Iterative computational and rational design generates diverse PET hydrolases for plastic depolymerization

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By Brenna Norton-Baker, Benjamin Fram, Nicole N. Thadani, Evan Komp, Yang Su, Natasha Murphy, Samuel Lim, Erika Erickson, Nathan Rollins, Japheth E. Gado, Courtney Shearer, Irimpan I. Mathews, Ian Truebridge, Christopher D. Bahl, Ritimukta Sarangi, Debora S. Marks, John McGeehan, Chris Sander, Gregg T. Beckham, Nicholas Gauthier, Olateju O. Storment, Maria Llases
| Nature Verified
Abstract Evolutionary relationships among homologous enzymes can be leveraged to introduce large numbers of amino acid substitutions for improved functional properties. Here, we combine evolution-informed design (EVdesign) with rational design to engineer improved poly(ethylene terephthalate) (PET) hydrolases (PETases).
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