Olcay Dilken

FCD functional capillary density FOV field of view HVM handheld intravital microscopy IDF incident dark field OPS orthogonal polarized spectral PPV proportion of perfused vessels PVD perfused vessel density RBCv red blood cells velocity SDF sidestream dark field TVD total vessel density 1 Introduction A healthy microcirculation is a core element for maintaining the balance between oxygen delivery to tissue and oxygen consumption by the cells, to sustain organ function.

Perioperative acute kidney injury (AKI) caused by ischemia-reperfusion (IR) is a significant contributor to mortality and morbidity after major surgery. Furosemide is commonly used in postoperative patients to promote diuresis and reduce tissue edema. However, the effects of furosemide on renal microcirculation, oxygenation and function are poorly understood during perioperative period following ischemic insult. Herein, we investigated the effects of furosemide in rats subjected IR insult.