Thomas O'Leary

Abstract Embryogenesis is remarkably robust to temperature variability, yet there is limited under- standing of the homeostatic mechanisms that offset thermal effects during early development. Here, we measured the thermal acclimation response of upper thermal limits and profiled chro- matin state and the transcriptome of D. melanogaster embryos (Bownes Stage 11) using single-nuclei multiome ATAC and RNA sequencing.

Abstract In organisms with complex life cycles, life stages that are most susceptible to environmental stress may determine species persistence in the face of climate change. Early embryos of Drosophila melanogaster are particularly sensitive to acute heat stress, yet tropical embryos have higher heat tolerance than temperate embryos, suggesting adaptive variation in embryonic heat tolerance.

The Supreme Court of Canada (the Court) recently granted leave to appeal in Earthco Soil Mixtures Inc. v. Pine Valley Enterprises Inc. (Pine Valley).1 This is a rare instance of the Court granting leave to appeal in a commercial matter and will be the first consideration of sale of goods legislation by the Court in over 30 years.