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Oleguer Castillo

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Validation of the HER2DX genomic test in first-line advanced HER2-positive breast cancer treated with trastuzumab, pertuzumab, and taxane - npj Breast Cancer

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By Marcin Kubeczko, Sandra Balanta Cobo, Rodrigo Sánchez-Bayona, Ewa Chmielik, Esther Sanfeliu, María Rey, Maria rey Verified, Francisco Pardo, Angela Aguirre, Esther Carcelero, Barbara Adamo, Maria Espie Vidal, María Vidal Verified, Milana Bergamino, Julia Maues, Guillermo Villacampa, Laia Paré, Eva Ciruelos, Aleix Prat, Michal Jarzab, Fara Brasó-Maristany, Bartłomiej Pyciński, Jesús Soberino, Oleguer Castillo, Aleksandra Lesniak, Malgorzata Oczko-Wojciechowska, Patricia Villagrasa
| Nature Verified
Abstract Trastuzumab, pertuzumab, and a taxane (THP) has been the standard first-line therapy for HER2+ advanced breast cancer for over a decade. With new regimens emerging, genomic tools like HER2DX may help identify patients who benefit durably from THP versus those requiring intensification. Here, baseline tumor tissue from 122 patients with HER2+ treated with THP in Poland was tested with HER2DX.
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