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Abstract Netrin‑1, a secreted protein initially characterized for its role in axon guidance, has emerged as a critical mediator of cancer progression. Preclinical studies with the anti‑netrin‑1 antibody NP137, which blocks the netrin‑1–UNC5B interaction, have demonstrated reactivation of tumor suppressor functions and sensitization of cancer cells to chemotherapy.
SHARPIN expression and importance in melanoma. We examined the expression of LUBAC components in multiple cancer types and found that SHARPIN was upregulated in many cancers, including melanoma, compared with normal or benign tissues (Figure 1A and Supplemental Figure 1, A and B; supplemental material available online with this article; https://doi.org/10.1172/JCI95410DS1).
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