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Olesia Omelko on Muck Rack

Olesia Omelko

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Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB - Communications Biology

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By Shu-Yu Chen, Thomas F. Gronauer, Sabine Schneider, Stephan A. Sieber, Michaela K. Fiedler, Olesia Omelko
| Nature Verified
Abstract Staphylococcus aureus signal peptidase IB (SpsB) is an essential enzyme for protein secretion. While inhibition of its activity by small molecules is a well-precedented mechanism to kill bacteria, the mode of activation is however less understood. We here investigate the activation mechanism of a recently introduced activator, the antibiotic compound PK150, and demonstrate by combined experimental and Molecular Dynamics (MD) simulation studies a unique principle of enzyme stimulation.
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