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Olfat Abduljabbar on Muck Rack

Olfat Abduljabbar

As seen in: BioRxiv
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Articles

RAN translation of C9ORF72-related dipeptide repeat proteins recapitulates hallmarks of motor neurone disease and identifies hypothermia as a therapeutic strategy in zebrafish

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By David Burrows, Lydia M. Castelli, Alexander McGown, Olfat Abduljabbar
| BioRxiv
Abstract Objective: Hexanucleotide repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A large body of evidence implicates DPRs as one of the main drivers of neuronal injury in cell and animal models. Methods: A pure RAN translation zebrafish model of C9orf72-ALS was generated.
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