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Oline Chantell Hollmann on Muck Rack

Oline Chantell Hollmann

As seen in: Nature
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Articles

Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy

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By Rasmus Rydbirk, Jonas Folke, Henriette Haukedal, Andrea Martinez, Irene Vargas, Camila Gherardelli, Sofia Sepulveda, Adam T Szafran, Michael Mancini, Sanne Simone Kaalund, Tomasz Brudek, Lisette Salvesen, Sara Bech, Justyna Okarmus, Peter V. Kharchenko, Morten A. Meyer, Claudio Soto, Kristine Freude, Abhisek Mukherjee, Susana Aznar, Konstantin Khodosevich, Simone McGarry, Oline Chantell Hollmann
| Nature Verified
Abstract Multiple system atrophy (MSA) is a rare, age-related neurodegenerative disease that shares clinical and pathological features with Parkinson’s disease (PD) but presents a more devastating disease course. To elucidate the distinct cellular pathophysiology, we performed single-nucleus RNA sequencing on postmortem striatal brain tissue from 7 MSA and 12 PD patients, and 10 non-neurological cases.
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