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Olivia Lucas on Muck Rack

Olivia Lucas

As seen in: Nature, Sydney Morning Herald, The Age, JD Supra, WAtoday, NatCen, European Urology Focus, West Side Rag, The Indiana Lawyer, StaffsLive
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Articles

Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER - Nature Genetics

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By Olivia Lucas, Sophia Ward, Abigail Bunkum, Alexander Frankell, David Moore, Mark Hill, Daniele Marinelli, Cristina Naceur-Lombardelli, Haoran Zhai, Michelle Dietzen, Samuel Aparicio, TRACERx consortium, Nicholas McGranahan, Mariam Jamal-Hanjani, Nnennaya Kanu, Charles Swanton, Rija Zaidi
| Nature Verified
Abstract Proliferation is a key hallmark of cancer, but whether it differs between evolutionarily distinct clones co-existing within a tumor is unknown. We introduce the Single-cell Proliferation Rate Inference in Non-homogeneous Tumors through Evolutionary Routes (SPRINTER) algorithm that uses single-cell whole-genome DNA sequencing data to enable accurate identification and clone assignment of S- and G2-phase cells, as assessed by generating accurate ground truth data.
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Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution - Nature Communications

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By Michelle Dietzen, Haoran Zhai, Olivia Lucas, Oriol Pich, Christopher Barrington, Wei-Ting Lu, Sophia Ward, Robert Hynds, Simone Zaccaria, Charles Swanton, Nicholas McGranahan
| Nature Verified
Abstract During each cell cycle, the process of DNA replication timing is tightly regulated to ensure the accurate duplication of the genome. The extent and significance of alterations in this process during malignant transformation have not been extensively explored. Here, we assess the impact of altered replication timing (ART) on cancer evolution by analysing replication-timing sequencing of cancer and normal cell lines and 952 whole-genome sequenced lung and breast tumours.
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Society Watch 2024: Understanding the new generation of voters

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By Ekaterina Khriakova, Joe Crowley, Crescenzo Pinto, Olivia Lucas
| NatCen
Executive summary Generations are having a moment “Baby Boomers”, “Millennials”, “Gen Z”—these labels have moved from market research and opinion pieces into everyday conversations. Widely used by writers and journalists, they are increasingly present in political debates in living rooms, Parliament, and on social media. As age becomes the biggest demographic divide in British politics (Curtice et al.
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