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Omar Avila Monge

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Articles

PTPN2 inhibition unleashes response to STING agonism in head and neck squamous cell cancer

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By Zehua Li, Cong Fu, Kartik Sehgal, Ann Marie Egloff, Tran C. Thai, Cun Lan Chuong, Yaiza Senent, Benjamin K. Eschle, Koji Haratani, Elena Ivanova, Marco Campisi, Navin R. Mahadevan, John Quadarella, Patrick C. Gedeon, Jonathan D Schoenfeld, Michihisa Kono, Caroline G. Fahey, Kenneth Ngo, Cloud Paweletz, Prafulla C. Gokhale, Robert T. Manguso, Ravindra Uppaluri, David A. Barbie, Omar Avila Monge, Maia Shea Lineberry, Chayapatou Chayawatto
| Nature Verified
Abstract cGAS-STING signaling can promote antitumor immunity, and tumor cell STING is suppressed in a variety of cancer subtypes that resist immune checkpoint blockade. Although STING agonists have failed clinical trials, precision approaches targeting restoration of tumor cell STING expression have yet to be explored.
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