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Omer Bar-Yosef on Muck Rack

Omer Bar-Yosef

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Articles

Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes

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By Natascha Roehlen, Linyi Zhu, Elad Jacoby, Omer Bar-Yosef
| Science Magazine Verified
LATEST NEWS Abstract Patients with single large-scale mitochondrial DNA (mtDNA) deletion syndromes (SLSMDs) usually present with multisystemic disease, either as Pearson syndrome in early childhood or as Kearns-Sayre syndrome later in life. No disease-modifying therapies exist for SLSMDs. We have developed a method to enrich hematopoietic cells with exogenous mitochondria, and we treated six patients with SLSMDs through a compassionate use program.
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