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Oncolines B.V

As seen in: Frontiers
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Combined cellular and biochemical profiling of Bruton’s tyrosine kinase inhibitor nemtabrutinib reveals potential application in MAPK-driven cancers

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By van den Bossche, de Roos, Daphne J. F, Oncolines B.V
| Frontiers
1 Background Cancer cell panel profiling is the parallel testing of drugs on large panels of human cancer cell lines in cell viability assays (1). Predictive biomarkers of drug response can be identified by relating drug sensitivity to genomic information of the cell lines (2–7). In addition, comparing the sensitivity profile of different drugs profiled on the same cell line panel can help in elucidating their biochemical mechanisms of action (8).
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