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Ophir Shwarzbard

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Articles

Single-Nucleotide m6A Mapping Uncovers Redundant YTHDF Function in Planarian Progenitor Fate Selection

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By Yarden Yesharim, Ophir Shwarzbard, Jenny Barboy-Smoliarenko, Ran Shachar
| BioRxiv
Abstract Cell fate decisions require tight regulation of gene expression. In planarians -- highly regenerative flatworms -- the mRNA modification N6-methyladenosine (m6A) modulates progenitor production and fate. However, the mechanisms governing m6A deposition in the planarian transcriptome -- and the role of their expanded family of YTHDF m6A reader proteins in orchestrating biological functions -- remain unclear.
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