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Articles by Bjorn Forsberg
In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7 - Nature Communications
Abstract Targeting the Frizzled family (FZD1-10) of WNT receptors pharmacologically has, despite substantial therapeutic potential, proven difficult. Given an almost complete lack of validated, effective small molecules targeting FZDs, no putative ligand binding site has so far been identified. In order to target FZD7, a potential target for the treatment of intestinal tumors, we combine an approach of adapted docking setups and large molecular library docking screens, identifying compound C407.
[2401.01826] Data-Driven Power Modeling and Monitoring via Hardware Performance Counters Tracking
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A robust normalized local filter to estimate compositional heterogeneity directly from cryo-EM maps - Nature Communications
Abstract Cryo electron microscopy (cryo-EM) is used by biological research to visualize biomolecular complexes in 3D, but the heterogeneity of cryo-EM reconstructions is not easily estimated. Current processing paradigms nevertheless exert great effort to reduce flexibility and heterogeneity to improve the quality of the reconstruction. Clustering algorithms are typically employed to identify populations of data with reduced variability, but lack assessment of remaining heterogeneity.
Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography
Lastly, we find that the structure of the non-infectious intracellular rotavirus TLP differs from the fully infectious mature virion. The activation of the virion is caused by trypsin digestion in the small intestine of sites in the loop connecting the head and trunk domains of VP4 (Figure 7). However, it is not well understood how the cleavages within VP4 result in greater infectivity.
Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2
Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2 Dari Kimanius, Bjorn O Forsberg, Sjors Scheres, Erik Lindahl bioRxiv 059717; doi: http://dx.doi.org/10.1101/059717
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