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Orhan Berk Imeci on Muck Rack

Orhan Berk Imeci

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Articles

Protective effects of dexpanthenol on experimental colitis in young rats: modulation of p53/BAX/BCL2 and RIPK1/RIPK3/MLKL signaling with anti-inflammatory activity

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By Abdulkerim Elmas, Halil Asci, Muhammet Yusuf Tepebasi, Abdurrahman Gulal, Mustafa Akçam, Ozlem Ozmen, Orhan Berk Imeci, Muhammed Burak Selver
| Nature Verified
Abstract Inflammatory bowel disease features chronic inflammation and epithelial barrier loss, driven by apoptosis, necroptosis, and oxidative stress. Dexpanthenol (DEX), a pantothenic acid derivative and CoA precursor, has antioxidant and tissue-protective properties, but its efficacy in colitis is unclear. Thirty-two 8-week-old female Wistar albino rats were randomized to Control, Colitis, Colitis+DEX (500 mg/kg i.p. for 5 days after induction), or DEX-only (n = 8/group).
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