Ori Braten on Muck Rack

Ori Braten

As seen in: Lung Cancer
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Tumor Treating Fields (TTFields) downregulate the Fanconi Anemia-BRCA pathway and increase the efficacy of chemotherapy in malignant pleural mesothelioma preclinical models

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By Mijal Munster, Helena Mumblat, Antonia Martinez-Conde, Ori Braten
| Lung Cancer
Highlights • TTFields are cytotoxic to pleural mesothelioma cells at optimal frequency of 150 kHz. • TTFields attenuate MPM tumor progression in murine models. • TTFields increase DNA damage in MPM, as previously seen in glioblastoma and NSCLC. • TTFields impair DNA damage repair in MPM, specifically the FA-BRCA pathway. • TTFields demonstrated synergism with cisplatin and additivity with pemetrexed.
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